![]() mirabilis strains causing urinary tract infections.īiofilm is a community of microorganisms encased in a self-produced matrix. Our research proves a beneficial impact of ascorbic acid with rutoside supplementation on biofilm of P. The ascorbic acid and rutoside combination, however, significantly decreased biofilm production. No synergism in fluoroquinolones with ascorbic acid, rutoside or both was found. ![]() ![]() The biofilm reduction rate was correlated with the increasing concentration of antibiotic used. Resultsīoth ciprofloxacin and norfloxacin inhibited biofilm formation by the tested strains. The metabolic activity of the biofilm treated with 0.4 mg/ml ascorbic acid, 0.02 µg/ml rutoside and chemotherapeutic agents (ciprofloxacin, norfloxacin) in the concentration range of 0.125–4.0 MIC (minimum inhibitory concentration) was assessed spectrophotometrically. mirabilis isolated from urinary tract infections in patients of the University Hospital No. The aim of the study was to determine the effect of selected fluoroquinolones and therapeutic concentrations of ascorbic acid and rutoside on biofilm formation by Proteus mirabilis. The combined action of fluoroquinolones and other antibacterial and anti-biofilm substances may extend the use of this therapeutic option by clinicians. Unfortunately, resistance to this group of drugs is currently growing. ![]() Fluoroquinolones are a group of antibiotics used in urinary tract infections.
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